BPCBPC-157
01 TRENDING TOPICS
02 RESEARCH FEED
Effects of Supplementation in Masters Athletes and Older Adults: A Narrative Review.
Supplementation use in athletes is common and increasing in popularity, especially for adults seeking improvements in athletic performance. However, the effects of supplementation for older adults or Masters athletes in…
Current sports medicine reports · 2026Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices.
Recently, methods for detecting small peptides in dried blood spots have been published. These procedures typically involve multiple sample preparation steps, resulting in labor-intensive and costly workflows. In the…
The Analyst · 2026Therapeutic peptides and proteins: Status and developments in drug delivery.
Peptides and proteins are the most dynamic class of biomolecules, performing a diverse range of physiological functions including biochemical catalysis, ion transport, molecular signaling, and genetic/epigenetic…
Journal of controlled release : official journal of the Controlled Release Society · 2026Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.
Background. This rat study reveals a new point: the considerable impact of unilateral adrenalectomy, severe vascular and multiorgan failure, occlusion/occlusion-like syndrome, and the stable gastric pentadecapeptide BPC…
Pharmaceuticals (Basel, Switzerland) · 2026BPC-157 and Its Novel Hybrid Analogs as Inhibitors of Acetylcholinesterase.
Acetylcholinesterase (AChE) inhibition remains a key therapeutic strategy in the management of neurodegenerative disorders such as Alzheimer's disease. In this study, the inhibitory potential of the gastric…
International journal of molecular sciences · 2026Current State of Orthobiologics in Treatment of Knee Osteoarthritis-Future Directions.
As the population ages, the incidence and prevalence of musculoskeletal degeneration, such as osteoarthritis, increase. While the currently accepted treatment options provide symptomatic and functional improvement, they…
International journal of molecular sciences · 2026Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury.
Ischemia-reperfusion (I/R) injury remains a major complication in peripheral arterial disease, characterized by oxidative stress, inflammation, and apoptosis. Body Protection Compound-157 (BPC 157), a stable gastric…
Scientific reports · 2026BPC-157 as an Investigational Peptide Therapeutic: Biopharmaceutical Challenges, Formulation Strategies, and Translational Development Barriers.
Background/Objectives: BPC-157 (body protection compound 157) is a synthetic pentadecapeptide derived from a gastric protein fragment with reported cytoprotective and regenerative properties across multiple organ…
Pharmaceutics · 2026Injectable Peptides in Sports Medicine: A Structured Narrative Review of Evidence, Safety, and Antidoping Implications.
BackgroundInjectable peptides are increasingly promoted for musculoskeletal recovery, tissue repair, and performance enhancements; however, clinical adoption has outpaced high-quality evidence and regulatory…
JBJS reviews · 2026Endothelium-Dependent Nitric Oxide-Mediated Vasorelaxant Effects of BPC 157 in Human Internal Mammary Artery.
Background/Objectives: Body Protection Compound-157 (BPC 157) is a stable gastric pentadecapeptide with cytoprotective, pro-angiogenic, and nitric oxide (NO)-modulating properties that has gained increasing attention…
Journal of clinical medicine · 2026Myotendinous Junction development and repair.
The myotendinous junction (MTJ) is the critical interface connecting muscle to tendon, enabling force transmission for movement and serving as the primary site of muscle injuries. Despite research into MTJ repair,…
Journal of orthopaedic translation · 2026Peptide Therapies in Thyroid Health: Emerging Applications in Endocrine and Immune Modulation.
Thyroid disorders, particularly autoimmune conditions such as Hashimoto's thyroiditis, are frequently associated with persistent systemic symptoms despite biochemical normalization with standard hormone replacement,…
Integrative medicine (Encinitas, Calif.) · 2026Regenerative Medicine Approaches to Craniofacial and Corneal Neuropathic Pain.
Craniofacial and corneal neuropathic pain are disabling conditions characterized by persistent pain that is frequently refractory to conventional pharmacologic and interventional therapies. These disorders arise from…
Pharmaceuticals (Basel, Switzerland) · 2026Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives.
Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes. While several peptide drugs have undergone rigorous approval processes that…
International journal of molecular sciences · 2026Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Peptides are short chains of amino acids with a unique pharmacological niche between small-molecule drugs and large proteins. Their use in sports medicine is rapidly expanding, driven by patient demand for accelerated…
Sports medicine (Auckland, N.Z.) · 2026Annual Banned-Substance Review 18th Edition-Analytical Approaches in Human Sports Drug Testing 2024/2025.
Alongside the considerable advances and accomplishments in drug research and development, the breadth of anti-doping research topics has also continued to grow. This is particularly relevant not only to provide…
Drug testing and analysis · 2026Cytoprotection as a Unifying Strategy for Hemorrhage and Thrombosis: The Role of BPC 157 and Related Therapeutics.
This review presents an innovative and timely exploration of how cytoprotection can serve as a cohesive therapeutic approach by which to address the hemorrhage-thrombosis paradox. Presenting counteraction of both…
Pharmaceuticals (Basel, Switzerland) · 2026From Regeneration to Analgesia: The Role of BPC-157 in Tissue Repair and Pain Management.
Body Protective Compound-157 (BPC-157) is a synthetic pentadecapeptide derived from gastric proteins that has demonstrated notable reparative and anti-inflammatory properties across diverse preclinical models.…
International journal of molecular sciences · 2026Stable Gastric Pentadecapeptide BPC 157 as a Therapy of Severe Electrolyte Disturbances in Rats.
This review explores the therapeutic potential of the stable gastric pentadecapeptide BPC 157 in addressing electrolyte imbalances, specifically hyperkalemia, hypokalemia, hypermagnesemia, and hyperlithiemia. In…
Current neuropharmacology · 2026Antihypertensive Peptides and Hydrolysates Derived from Plant Proteins and Their Bioavailability
Foods (Basel, Switzerland) · 2026Tendon, Ligament, and Muscle Injury, Osteotendinous, Myotendinous, and Muscle-to-Bone Junction Therapy Perspectives with Growth Factors and Stable Gastric Pentadecapeptide BPC 157-A Review.
As a novel theoretical and practical advantage, preclinical to clinical evidence, this systematic review of PRP, growth factors, and stable gastric pentadecapeptide BPC 157 efficacy in complex musculoskeletal and…
Pharmaceuticals (Basel, Switzerland) · 2026Tendon, Ligament, and Muscle Injury, Osteotendinous, Myotendinous, and Muscle-to-Bone Junction Therapy Perspectives with Growth Factors and Stable Gastric Pentadecapeptide BPC 157—A Review
Pharmaceuticals (Basel, Switzerland) · 2026Regulation of Nosema ceranae gene expression by Bidens pilosa phytogenic treatment in infected honey bees.
IntroductionNosema ceranae is an obligate microsporidian parasite that causes nosemosis in honey bees (Apis mellifera).MethodsIn controlled laboratory cage experiments, newly emerged worker bees were experimentally…
Frontiers in insect science · 2026Scrolling for science: Assessing the quality and accuracy of Crohn's disease-related content on Instagram reels.
BackgroundThere is a concerning trend of misinformation of healthcare related content on social media. Recent studies have examined themes and narratives about Crohn's disease but have not quantitatively assessed the…
PloS one · 202603 FACT BANK
A synthetic 15-amino-acid peptide — a "pentadecapeptide" — based on a protective compound found in human gastric juice.
Mostly in animal models: stomach and gut-lining healing, tendon, ligament, muscle and bone repair, and blood-vessel growth.
Linked to angiogenesis, growth-factor signalling and the nitric-oxide system — associated with faster tissue repair in models.
GEPPPGKPADDAGLV — fifteen residues. Marketed as a stable "Body Protection Compound," which is where the BPC name comes from.
Not FDA-approved. Sold as a research chemical; its US compounding status is under active FDA review (PCAC, Jul 2026).
Banned by WADA under S0 (non-approved substances) — prohibited at all times, in and out of competition.